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December 8, 2025GeroScienceOpen Access

Multimorbidity, frailty and polypharmacy in European and Asian patients with atrial fibrillation: a comparison of two regional prospective observational registries

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Authors

GRGiulio Francesco RomitiTBTommaso BucciBCBernadette Corica

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Overview

Observational analysis reveals multimorbidity and frailty increase cardiovascular event risk in AF patients, suggesting regional disparities.

Key Points

  • Risk of cardiovascular events was higher in patients with multimorbidity and frailty, particularly in Asian AF patients, indicating regional differences in patient profiles.
  • Frail Asian patients were less likely to be prescribed oral anticoagulants compared to Europeans, highlighting disparities in treatment approaches.
  • Multimorbidity and polypharmacy prevalence was significantly higher among European patients than their Asian counterparts, emphasizing differing health challenges in regions.
  • Findings support the need for tailored management strategies for AF patients based on multimorbidity and frailty characteristics.

Cite This Study

Romiti et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc5ehttps://doi.org/10.1007/s11357-025-02026-5
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical Complexity in Patients with Atrial Fibrillation: Exploring Differential Risk Profiles from European and Asian Cohorts2025 · 10 citations
  2. 2Frailty in Older Patients With Atrial Fibrillation and Its Relationship With Anticoagulant Use: A Multi‐Centred Observational Study in New South Wales2025 · 2 citations
  3. 3Ethnic differences in clinical outcomes following major bleeding in atrial fibrillation patients: a report from two prospective regional registries in Europe and Asia2025 · 4 citations
  4. 4Real-World outcomes of oral anticoagulation in patients with atrial fibrillation at high risk of both bleeding anand Asia-Pacificd stroke: observational evidence from three international registries from middle East, Europe2025 · 4 citations
  5. 5Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: An individual patient-level meta-analysis of randomised trials2025