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August 2, 2025

Combination of heart failure and atrial fibrillation worsens ethnicity-related disparity: An individual patient-level meta-analysis of randomised trials

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Authors

ACAsgher ChampsiSFSebastian FoxEHEvan J Hardy

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Overview

Meta-analysis reveals increased mortality in non-white patients with heart failure and atrial fibrillation, indicating significant health disparities.

Key Points

  • Non-white patients with heart failure experience higher mortality rates compared to white patients.
  • The combination of heart failure and atrial fibrillation increases the mortality hazard ratio for non-white patients to 2.05.
  • Analysis included 16,713 patients from 12 randomized trials, focusing on ethnicity and comorbidity effects.
  • Findings highlight the critical need for targeted interventions to address ethnicity-related health disparities in heart failure.

Cite This Study

Champsi et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8cffbdhttps://doi.org/10.1101/2025.07.31.25332510
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of Atrial Fibrillation in patients with Heart Failure and vice versa: Incidence, risk factors, and their impact on survival2026
  2. 2Multimorbidity, frailty and polypharmacy in European and Asian patients with atrial fibrillation: a comparison of two regional prospective observational registries2025 · 4 citations
  3. 3Clinical and Therapeutic Phenotypic Clustering and Prognostic Stratification in Heart Failure Patients With Atrial Fibrillation2026
  4. 4Heart failure in patients with recently diagnosed atrial fibrillation: findings from the GLORIA-AF Registry Phase III2025 · 5 citations
  5. 5Racial disparities in the mortality and health-care resource utilization of heart failure patients with chronic obstructive pulmonary disease2025