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December 8, 2025BloodOpen Access

Unifying the classification of acute myeloid leukemia, myelodysplasia-related: A multi-institutional experience

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Authors

ESEytan M. SteinWXWenbin Xiao

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Overview

Multinational assessment finds RUNX1 impacts gene mutations in acute myeloid leukemia, suggesting improved classification utility.

Key Points

  • Overall survival among AML diagnostic categories significantly varied, highlighting the prognostic distinction of acute myeloid leukemia-MR.
  • Multivariable analysis identified stem cell transplant as a significant prognostic factor in acute myeloid leukemia outcomes.
  • Analysis employed Kaplan-Meier methods and Cox proportional-hazard models to assess survival factors across multiple centers.
  • RUNX1 inclusion in genetic profiles may enhance the classification of acute myeloid leukemia-MR subtypes.

Cite This Study

Stein et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc4fhttps://doi.org/10.1182/blood-2025-219
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  1. 1Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025
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  3. 3A novel multi-target NGS application for molecular monitoring of measurable residual disease in Acute Myeloid Leukemia2025 · 2 citations
  4. 4Impact of minimal residual disease and next generation sequencing discordance in AML following induction with hypomethylating agent + venetoclax.2025
  5. 5Prognostic relevance of multiparameter flow cytometry-based MRD assessment in patients with FLT3-ITD mutated AML considering concomitant mutations including DNMT3A/NPM1/WT1 mutation2025 · 1 citations