December 8, 2025Blood

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

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Authors

JTJose TinajeroCity Of Hope National Medical Center SOSalman OtoukeshCity Of Hope National Medical Center SPSunmin ParkCity Of Hope National Medical Center

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Implication

Observational analysis reports increased drug levels in patients on tacrolimus or sirolimus with belumosudil, indicating close therapeutic drug monitoring is necessary.

Key Points

Tacrolimus and sirolimus levels significantly increased after adding belumosudil, suggesting important dose adjustments are needed.
Median increases were +25.8% for Tacrolimus and +37.4% for Sirolimus after switching to belumosudil; severe toxicities were rare.
Retrospective review of 68 patients revealed a prevalence of supratherapeutic levels of TAC and SIRO among those on belumosudil.
Drug-drug interactions between tacrolimus and sirolimus were confirmed, highlighting the need for careful monitoring post-transplant.

Cite This Study

Tinajero et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc11 https://doi.org/10.1182/blood-2025-7612

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Implication

Observational analysis reports increased drug levels in patients on tacrolimus or sirolimus with belumosudil, indicating close therapeutic drug monitoring is necessary.

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

The effect of belumosudil on the therapeutic monitoring of tacrolimus and sirolimus in allogeneic hematopoietic transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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