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December 8, 2025Blood

Belumosudil in pediatric patients with steroid-refractory chronic graft-versus-host disease

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Authors

WYWenyu Yang

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Overview

Observational analysis showed 76.9% overall response rate in pediatric patients with SR-cGVHD, indicating belumosudil may improve treatment outcomes.

Key Points

  • Belumosudil showed a 76.9% overall response rate in pediatric patients with steroid-refractory chronic graft-versus-host disease.
  • The median time to response was 7 weeks, with a failure-free survival rate of 68.6% and overall survival rate of 100%.
  • Observational analysis included 13 pediatric patients who received belumosudil after failing multiple lines of treatment.
  • Highlights that belumosudil was well tolerated, with comparable adverse effects rates to the control group.

Cite This Study

Wenyu Yang (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd07https://doi.org/10.1182/blood-2025-7834
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Belumosudil for chronic graft-versus-host disease in children under 12: A retrospective analysis of effectiveness and safety2025
  2. 2Efficacy and Safety of Belumosudil as Compared with Best Available Therapy for the Treatment of cGVHD in the US2025
  3. 3Investigating belumosudil in children with refractory moderate-to-severe chronic graft-versus-host disease: Design of a phase 1/2 study2025
  4. 4Efficacy and safety of the ROCK2-inhibitor belumosudil for chronic gvhd treatment: Multicenter retrospective analysis of a large german-austrian cohort of the belumosudil managed-access program.2025
  5. 5Response dynamics to belumosudil in chronic graft-versus-host disease: Characterizing late responses and organ-specific response expectations from the rockstar study2025