December 8, 2025BloodOpen Access

Unexplained bleeding and a hidden inhibitor: A case of late-onset acquired hemophilia A

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Discussion

Case presentation shows severe hemorrhage in elderly patient with acquired hemophilia A, indicating urgent immunosuppressive therapy is needed.

Patient displayed profound anemia and a large rectus sheath hematoma, necessitating urgent care for hemophilia A.
Laboratory tests revealed isolated aPTT prolongation and low factor VIII activity with a high inhibitor level.
Management involved supportive measures and immunosuppressive therapy after initial inadequate response to Factor VIII treatment.
Awareness of acquired hemophilia A is critical for early diagnosis and intervention to reduce mortality risk.

Sharma et al. (2025) studied this question.

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Case presentation shows severe hemorrhage in elderly patient with acquired hemophilia A, indicating urgent immunosuppressive therapy is needed.