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December 8, 2025BloodOpen Access

CART–ASCT–CART2 sandwich regimen as frontline therapy: A phase II trial in patients with primary plasma cell leukemia

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Authors

JXJingYu XuQBQirui BaiYLYuntong Liu

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Overview

Phase II trial shows CART–ASCT–CART2 regimen improves outcomes in primary plasma cell leukemia, indicating potential benefits over previous therapies.

Key Points

  • Eighty-three percent of patients completed the CART–ASCT–CART2 regimen with positive outcomes.
  • Among patients evaluated, all achieved stringent complete response following the therapy.
  • Single-arm, open-label phase II trial evaluated CART–ASCT–CART2 regimen for pPCL patients.
  • Encouraging findings suggest a need for larger studies to confirm long-term efficacy.

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236daa0https://doi.org/10.1182/blood-2025-4067
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