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December 8, 2025Blood

Real-world experience with first-line regimens in transplant-ineligible patients with multiple myeloma

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Authors

EGEngin GulSSSmriti SharmaJSJiandong Su

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Overview

Retrospective study reports high response rates and low early mortality in transplant-ineligible multiple myeloma patients using DRd and RVd.

Key Points

  • Overall response rates with DRd and RVd reached approximately 95%, indicating the effectiveness of these regimens.
  • The observational study assessed treatment responses in 1,085 transplant-ineligible patients with multiple myeloma over several years.
  • Significantly lower early mortality rates were observed with DRd, highlighting its potential advantage as a primary treatment option.
  • These findings emphasize the importance of evaluating progression-free survival as DRd's long-term efficacy data becomes available.

Cite This Study

Gul et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da78https://doi.org/10.1182/blood-2025-2798
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transition to IRD maintenance after DRD induction significantly deepens response in transplant-ineligible NDMM: A prospective multicenter study2025
  2. 2First-line treatment in patients with transplant-ineligible, newly diagnosed multiple myeloma by age, frailty, and comorbidity2025
  3. 3Dara-RVD in newly diagnosed multiple myeloma: Real-world clinical practice2025
  4. 4Carfilzomib, lenalidomide, and dexamethasone (KRd) versus bortezomib, lenalidomide and dexamethasone (VRd) in patients with newly diagnosed multiple myeloma (NDMM) – interim results from the randomized Phase III COBRA trial.2025 · 3 citations
  5. 5Real-world stratified treatment strategies in transplant-eligible newly diagnosed multiple myeloma: A multicohort study2025