December 8, 2025BloodOpen Access

Targeting mitochondrial metabolism to suppress neutrophil overactivation in sepsis: Therapeutic potential of the mitochondrial uncoupler BAM15

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Authors

ACAwirut Charoensappakit ATArsa ThammahongChulalongkorn University MPMonvasi Pachinburavan

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Implication

Observational analysis finds mitochondrial uncoupler BAM15 attenuates neutrophil overactivation in sepsis, suggesting a new anti-inflammatory strategy.

Key Points

Neutrophils show increased mitochondrial ROS, driving overactivation during sepsis, and mitochondrial uncoupler BAM15 effectively reduces this phenomenon.
Patients with sepsis presented with heightened metabolic activity and altered neutrophil phenotypes indicated by elevated markers such as CD11b and reduced CD62L.
Assessment using extracellular flux analysis demonstrated significant changes in mitochondrial function, correlating MMP and metabolic profiles in neutrophils from sepsis patients.
Mitigating excessive neutrophil responses through mitochondrial modulation may present a novel approach to reduce inflammation associated with sepsis.

Cite This Study

Charoensappakit et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9a9 https://doi.org/10.1182/blood-2025-2981

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Implication

Observational analysis finds mitochondrial uncoupler BAM15 attenuates neutrophil overactivation in sepsis, suggesting a new anti-inflammatory strategy.

Targeting mitochondrial metabolism to suppress neutrophil overactivation in sepsis: Therapeutic potential of the mitochondrial uncoupler BAM15

Discussion

Member takes

Implication

Key Points

Cite This Study

Targeting mitochondrial metabolism to suppress neutrophil overactivation in sepsis: Therapeutic potential of the mitochondrial uncoupler BAM15

Discussion

Member takes

Implication

Key Points

Cite This Study

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