September 10, 2025Microbiology SpectrumOpen Access

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis

View Full Paper

Ask AI

Bookmark

Authors

TJTing JiSichuan University TZTingting ZhaoSun Yat-sen University SLS. Alice LongArmy Medical University

Discussion

Member takes

Implication

This study demonstrates how microvesicle-transferred mitochondria alter macrophage function in sepsis, suggesting cGAS-STING as a novel therapeutic target.

Key Points

Microvesicle-transferred mitochondria trigger inflammation in macrophages, leading to organ injury in sepsis.
The study found that metformin inhibits mitochondrial reactive oxygen species and cGAS-STING signaling, reducing cytokine production.
LPS-primed macrophages transfer mitochondria via microvesicles, reprogramming recipient macrophages into damaging M1 states.
Identifying the cGAS-STING-IFN-β pathway as a target may allow for innovative treatments for sepsis.

Cite This Study

Ji et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786372 https://doi.org/10.1128/spectrum.00781-25

View Full Paper

Ask AI

Bookmark

Implication

This study demonstrates how microvesicle-transferred mitochondria alter macrophage function in sepsis, suggesting cGAS-STING as a novel therapeutic target.

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider