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December 8, 2025BloodOpen Access

Multi-dimensional transcriptomic profiling reveals novel tumor microenvironment landscape and subtype-specific therapeutic Vulnerabilities of MALT lymphomas

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Authors

KKKai KangYYYuqi YangAZAilin Zhao

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Overview

Bulk RNA and single-nucleus sequencing reveals therapeutic targets in MALT lymphoma tumor microenvironment, indicating specific vulnerabilities across subtypes.

Key Points

  • Mesenchymal subtype demonstrated increased drug sensitivity to anti-angiogenic agents, while the Depleted subtype showed greater responsiveness to cell cycle-targeting therapies.
  • Non-negative matrix factorization categorized tumor microenvironments into three distinct subtypes: Mesenchymal, Inflammatory, and Depleted.
  • Cell-cell communication analysis indicated neutrophils and tumor-associated macrophages drive angiogenesis via the VEGF pathway in the Mesenchymal subtype.
  • Study highlights the importance of understanding tumor microenvironment subtypes for developing personalized treatment strategies for MALT lymphomas.

Cite This Study

Kang et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d966https://doi.org/10.1182/blood-2025-1751
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