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December 8, 2025BloodOpen Access

Defective mitophagy of CD4+T cells in ITP via NAD+/SIRT1 reduction

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Authors

MXMengyu XiaoMZMengtong ZangLWLulu Wang

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Overview

Analysis reveals NAD+/SIRT1 axis deficiency correlates with mitophagy impairment in ITP CD4+ T cells, suggesting therapeutic insights.

Key Points

  • Defective mitophagy in ITP CD4+ T cells leads to immune dysregulation.
  • NAD+ and SIRT1 expression in ITP CD4+ T cells is significantly reduced, indicating metabolic dysfunction.
  • In vitro SIRT1 agonist treatment enhances mitophagy and mitochondrial function in ITP CD4+ T cells.
  • Targeted correction of NAD+/SIRT1 axis may offer new therapeutic avenues for immune balance in ITP.

Cite This Study

Xiao et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8f9https://doi.org/10.1182/blood-2025-1247
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