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August 1, 2025HemaSphereOpen Access

Mesenchymal stromal cells from JAK2V617F myeloproliferative neoplasms support healthy and malignant hematopoiesis in a humanized scaffold model in vivo

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Authors

AFAlessandra FerrelliSMSyed A MianMPMarion Piganeau

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Overview

Observational analysis shows mesenchymal stromal cells support hematopoiesis in myeloproliferative neoplasms, indicating key interactions with JAK2 V617F clones.

Key Points

  • Robust hematopoietic support was observed for healthy HSPCs by MSCs derived from polycythemia vera and essential thrombocythemia.
  • Engraftment of CRISPR-edited JAK2 V617F HSPCs was consistent in scaffolds with both healthy and MPN-derived stroma.
  • Research utilized a 3D scaffold model to establish a humanized xenograft mouse model, facilitating functional analysis.
  • Findings highlight the interactions between MSCs and JAK2 V617F clones, suggesting new treatment approaches for MPN.

Cite This Study

Ferrelli et al. (2025) studied this question.

synapsesocial.com/papers/68af73637567bf4f94fed35ahttps://doi.org/10.1002/hem3.70185
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