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December 8, 2025BloodOpen Access

Efficacy of motixafortide plus G-CSF versus plerixafor plus G-CSF for stem cell mobilization and collection in multiple myeloma: A single-center comparative analysis and interim Results from a prospective study in poor mobilizers

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Authors

SSSuhayla SarhanKGKristine GearyCCCorey Cutler

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Overview

Prospective analysis shows motixafortide improves CD34+ yield in poor mobilizers compared to plerixafor, despite increased adverse reactions.

Key Points

  • Motixafortide administration resulted in a significant greater fold-increase in pbCD34+ compared to plerixafor.
  • The median CD34+ yield on Day 1 was notably higher with motixafortide, at 4.12 million CD34+ cells/kg.
  • Adverse reactions were common with motixafortide, particularly injection site pain requiring medical management for many patients.
  • This analysis may inform treatment regimens for multiple myeloma patients who struggle with effective stem cell mobilization.

Cite This Study

Sarhan et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d88dhttps://doi.org/10.1182/blood-2025-4185
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Improved hematopoietic stem cell mobilization for gene therapy using single agent motixafortide in sickle cell disease2025
  2. 2Motixafortide + G-CSF hematopoietic stem cell mobilization in patients with multiple myeloma following quadruplet induction therapy2025
  3. 3Etoposide + cytarabine + pegfilgrastim vs cyclophosphamide + granulocyte colony-stimulating factor for stem-cell mobilization in patients with multiple myeloma: A phase III trial2025
  4. 4An open-label, multi-center Phase 2 study to assess the safety and efficacy of burixafor (GPC-100) and propranolol with G-CSF for the mobilization of hematopoietic progenitor cells in patients with multiple myeloma2025 · 1 citations
  5. 5Impact of pomalidomide-containing induction chemotherapy on hematopoietic stem cell mobilization in multiple myeloma: A retrospective cohort study2025