Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Hematopoietic stem cell transplantation with reduced toxicity myeloablative conditioning regimen for children and adults with sickle cell disease: A brazilian single center experience.

View Full Paper
Ask AI
Bookmark
Share

Authors

JDJuliana Bernardes Elias DiasRGRenata GuimarãesASAna Cristina Silva‐Pinto

Discussion

Loading...

Member takes

Overview

Observational analysis shows 93% overall survival in 60 patients with sickle cell disease after hematopoietic stem cell transplantation, suggesting a safe approach for treatment.

Key Points

  • Overall survival reached 93% at 2 years in patients with sickle cell disease after treatment.
  • Statistical analysis utilized R software, estimating survival metrics and comparing outcomes.
  • Bone marrow was the predominant stem cell source among patients undergoing treatment.
  • Findings highlight the viability of reduced toxicity conditioning regimens in hematopoietic stem cell transplantation.

Cite This Study

Dias et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d875https://doi.org/10.1182/blood-2025-4221
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Haploidentical hematopoietic stem cell transplantation in adults with severe sickle cell disease: Long-term outcomes using a modified conditioning regimen with peripheral blood stem cells.2025 · 1 citations
  2. 2Encouraging Outcomes of Hematopoeitic Stem Cell Transplantation in Pediatric Sickle Cell Disease- A Decade-Long Experience from the Developing World2025
  3. 3Reduced intensity haploidentical bone marrow transplantation in children with severe sickle cell disease (SCD): BMT CTN 15072025 · 4 citations
  4. 4Results of allogeneic hematopoietic stem cell transplantation from a genoidentical sibling after high-dose treosulfan-based conditioning in children with intermediate-risk acute myeloid leukemia in first clinical and hematological remission2025
  5. 5Expanding access in pediatrics: Outcomes of haploidentical transplantation with reduced intensity and peripheral blood stem cells2025