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December 8, 2025BloodOpen Access

HMGA1 chromatin regulator induces inflammatory signals and promotes atherogenesis in Tet2 mutant clonal hematopoiesis

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Authors

ZTZanshé ThompsonASAudrey-Ann SupremeMAMarios Arvanitis

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Overview

Observational analysis reveals decreased atherogenesis in Tet2 mutant mice with Hmga1 deficiency, highlighting inflammatory response pathways in atherogenesis.

Key Points

  • Atherogenesis decreased dramatically in Tet2 mutant mice with Hmga1 heterozygous deficiency, showcasing a vital regulatory role.
  • Significant reductions in inflammatory cytokines linked to atherosclerosis observed due to Hmga1 haploinsufficiency in Tet2 mutants.
  • Assessment using bone marrow transplantation followed by single cell RNA sequencing provided insights into Hmga1's mechanistic role.
  • This work highlights HMGA1's influence on inflammatory responses in clonal hematopoiesis and potential therapeutic targets for atherosclerosis.

Cite This Study

Thompson et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d828https://doi.org/10.1182/blood-2025-3177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1HMGA1 chromatin regulators drive transcriptional networks involved in megakaryocyte expansion, fibrosis, and sensitivity to interferon signaling in JAK2-V617F MPN2025
  2. 2HMGA1 chromatin regulators drive transcriptional networks governing cell cycle progression, immune escape, and menin-inhibitor resistance in KMT2A-r Acute Myeloid Leukemia2025
  3. 3Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics2025
  4. 4Human TET2-mutant clonal hematopoiesis expansion is driven by distinct inflammatory signaling responses in stem cells versus myeloid progeny.2025 · 8 citations
  5. 5Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis2025