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December 8, 2025BloodOpen Access

Single-cell multiomic profiling of gene mutation, chromatin accessibility, and gene expression in TET2-mutant clonal hematopoiesis

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Authors

MMMasanori MotomuraNSNobuo SezakiMNMasahiro Nakagawa

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Overview

Novel platform shows TET2 mutation alters gene regulation and hematopoietic lineage in clonal hematopoiesis, indicating implications for myeloid neoplasms.

Key Points

  • TET2 mutation affects gene expression and chromatin accessibility in hematopoietic lineage maturation.
  • Cells from TET2-MUT patients exhibited a significant differentiation bias toward myeloid lineages.
  • Observational analysis across TET2-MUT clonal hematopoiesis patients highlighted altered transcription factor activity.
  • Dysregulated maturation and altered cell cycle control may contribute to myeloid neoplasm predisposition.

Cite This Study

Motomura et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d817https://doi.org/10.1182/blood-2025-3164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Chromodomain helicase DNA binding protein CHD2 interacts with TET2 and regulates lineage defining transcription in hematopoietic stem and progenitor cells2025
  2. 2Beyond clonal hematopoiesis of indeterminate potential: Understanding how the trisomy 21 context promotes TET2 mutations2025
  3. 3Human TET2-mutant clonal hematopoiesis expansion is driven by distinct inflammatory signaling responses in stem cells versus myeloid progeny.2025 · 8 citations
  4. 4Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis2025
  5. 5Novel approaches to identify cellular vulnerabilities in TET2-dependent MDS2025