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December 8, 2025BloodOpen Access

Chromodomain helicase DNA binding protein CHD2 interacts with TET2 and regulates lineage defining transcription in hematopoietic stem and progenitor cells

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Authors

SBSonga BaeMSMamta P. SumiYZYahan Zhang

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Overview

Findings reveal CHD2's role in transcriptional control in hematopoietic stem and progenitor cells, suggesting links to myeloid malignancies.

Key Points

  • CHD2 interaction with TET2 promotes transcriptional fidelity in hematopoietic stem and progenitor cells, supporting normal hematopoiesis.
  • Global proteomic analysis showed a substantial overlap in CHD2 and TET2 interactomes, indicating shared functional pathways.
  • Chromatin immunoprecipitation identified 95% overlap between CHD2- and TET2-bound regulatory genes, critical for lineage specification.
  • Study highlights potential therapeutic targets in epigenetic mechanisms driving myeloid malignancies linked to TET2 mutations.

Cite This Study

Bae et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4aahttps://doi.org/10.1182/blood-2025-3237
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