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December 8, 2025BloodOpen Access

Deciphering clonal progression in MDS via longitudinal sequencing

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Authors

VDVikramjit DhillonDPDakshin PadmanabhanSBSuresh Kumar Balasubramanian

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Overview

Observational analysis revealed clonal evolution and shifts in molecular clusters in MDS patients, indicating prognostic value of longitudinal sequencing.

Key Points

  • Clonal evolution patterns were observed across molecular clusters in MDS patients, impacting survival outcomes.
  • Analysis of 122 patients with paired samples showed significant shifts in molecular classifications at relapse.
  • Next-generation sequencing identified 18 molecular clusters, with varying stability and prognostic significance.
  • Findings highlight the need for longitudinal sequencing to enhance MDS prognostication and monitor treatment response.

Cite This Study

Dhillon et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7a5https://doi.org/10.1182/blood-2025-2066
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  5. 5Clonal evolution and risk assessment in myelodysplastic syndromes (MDS): A prospective Study of dynamic IPSS-m validation and evolutionary trajectory modeling by the italian MDS foundation (FISIM)2025