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December 8, 2025Blood

Predictors of discordant end-of-treatment PET positivity in advanced-stage classical Hodgkin lymphoma patients with negative interim PET response

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Authors

AHAlaa Hamad

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Overview

Retrospective analysis identifies stage IV disease as a predictor of residual disease in classical Hodgkin lymphoma, suggesting the need for further evaluation beyond interim PET.

Key Points

  • Residual disease detected in 17.2% of patients with initial negative interim PET results.
  • Median follow-up duration was 28.8 months, with stage IV disease showing significant association with residual PET positivity.
  • Assessment involved logistic regression to identify predictors from clinical and laboratory data.
  • Findings indicate that stage IV classification may signal a higher risk of discordant end-of-treatment results.

Cite This Study

Alaa Hamad (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d723https://doi.org/10.1182/blood-2025-7139
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Also Consider

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  1. 1Treatment practices and outcomes of advanced stage classical Hodgkin lymphoma in India: An analysis from the hematology cancer consortium2025
  2. 2Interim and end-of-treatment FDG-PET demonstrate limited ability to predict 3-year progression-free survival with nivolumab-AVD in first-line treatment of advanced stage Hodgkin lymphoma: Imaging sub-analysis of Phase 3 S1826 study2025 · 5 citations
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  4. 4Prognostic value of minimal residual disease detection by circulating tumor DNA in Hodgkin lymphoma.2025
  5. 5Dose Escalation shows no benefit compared to continuing ABVD in Hodgkin's lymphoma patients with an interim PET deauville score of 42025