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December 8, 2025Blood

PET imaging biomarkers predict survival in peripheral T-cell lymphoma: A systematic review and meta-analysis.

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Authors

NMNeha Mehta‐ShahFHFrederick Hagemeister

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Overview

Meta-analysis shows PET imaging biomarkers predict survival outcomes in peripheral T-cell lymphoma, suggesting their clinical relevance.

Key Points

  • This research aims to evaluate the prognostic value of PET imaging biomarkers in peripheral T-cell lymphoma.
  • Conducted a systematic meta-analysis of 196 articles
  • Included treatment-naive adults with nodal PTCL
  • Analyzed hazard ratios for overall survival and progression-free survival
  • Reviewed 10 studies meeting inclusion criteria
  • Nine studies were retrospective and one was prospective
  • Baseline metabolic tumor volume correlated with worse progression-free survival and overall survival
  • Deauville scores at end-of-treatment were strongly predictive of survival outcomes
  • Identified significant inter-study variability and predictive value discrepancies

Cite This Study

Mehta‐Shah et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d300https://doi.org/10.1182/blood-2025-6299
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  2. 2Comparison of different response evaluation criteria in interim PET/computed tomography for diffuse large B-cell lymphoma: is Δtotal metabolic tumor volume a worthwhile measure?2025
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  4. 4Analysis of the role of baseline PET/CT in a prospective study of unselected patients: The UK MCL biobank2025
  5. 5Radiomic features from PET-CT enable diagnostic and prognostic stratification in peripheral T-cell lymphoma2025