Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Deciphering the role of EP300 in maintaining the enhancer landscape and lineage-specific epigenetic vulnerability in multiple myeloma

View Full Paper
Ask AI
Bookmark
Share

Authors

STSrikanth TalluriAJAdvait Joshi

Discussion

Loading...

Member takes

Overview

Investigation reveals EP300 regulates enhancer activity and promotes apoptosis in multiple myeloma, suggesting its therapeutic potential.

Key Points

  • Decreased cell viability and increased apoptosis were observed following EP300 degradation in multiple myeloma cell lines.
  • Transcriptomic analyses indicated significant changes in enhancer activity, with a reduction in key regulatory regions.
  • The study utilized methods such as shRNA, RNA sequencing, and mass spectrometry to assess the role of EP300 in multiple myeloma.
  • Findings highlight the importance of EP300 as a potential therapeutic target for high-risk multiple myeloma patients.

Cite This Study

Talluri et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6ddhttps://doi.org/10.1182/blood-2025-5735
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P300/CBP acetyltransferase inhibition and degradation disrupt oncogenic transcriptional programs and reveal epigenetic vulnerabilities in multiple myeloma2025
  2. 2Deciphering the cellular hierarchy of multiple myeloma uncovers a therapeutically exploitable EP300/TBX2 axis in LILRB4+ myeloma-initiating cells2025
  3. 3Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples2025
  4. 4Novel multifunctional degraders of EP300/CBP and IKZF1/3 with potent anti-myeloma activity2025
  5. 5Combinatorial DNMTs and EZH2 inhibition reprograms the H3K27me3 and DNAme-mediated onco-epigenome to suppress multiple myeloma proliferation2025 · 5 citations