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December 8, 2025BloodOpen Access

P300/CBP acetyltransferase inhibition and degradation disrupt oncogenic transcriptional programs and reveal epigenetic vulnerabilities in multiple myeloma

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Authors

OMOlga MotornaJSJake Shortt

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Overview

Analysis uncovers apoptotic effects from protein degradation in multiple myeloma, suggesting new therapeutic strategies.

Key Points

  • Inhibition of acetyltransferase P300/CBP induced significant apoptotic responses in multiple myeloma cells.
  • The use of various inhibitors demonstrated anti-proliferative effects in genetically diverse cell lines and xenografts.
  • Analysis of chromatin structure revealed minimal changes despite robust loss of acetylation, challenging existing paradigms.
  • Targeting protein degradation alongside acetyltransferase inhibition may amplify treatment efficacy in multiple myeloma.

Cite This Study

Motorna et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6c9https://doi.org/10.1182/blood-2025-5717
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Deciphering the role of EP300 in maintaining the enhancer landscape and lineage-specific epigenetic vulnerability in multiple myeloma2025
  2. 2Novel multifunctional degraders of EP300/CBP and IKZF1/3 with potent anti-myeloma activity2025
  3. 3HDAC inhibitors potentiate the efficacy of antineoplastic agents in acute megakaryoblastic leukemia via dual activation of apoptosis and pyroptosis2025
  4. 4Synthetic lethal targeting of PSMC2-dependent p97-adapted proteasome complexes that confer chemoresistance in multiple myeloma2025 · 1 citations
  5. 5CXXC1 is required for IRF4 chromatin binding and expression and regulates cellular fitness in lenalidomide-sensitive and -resistant myeloma cells2025