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December 8, 2025Blood

Post allo-HCT menin-inhibition enhances graft-versus-leukemia effects by endogenous retrovirus induction in AML and T-cell activation

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Authors

LSLennard Frederik SchwöbelASA. StellMPMarco Punta

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Overview

Analysis shows menin-inhibition boosts T-cell activation and interferon-stimulated genes in acute myeloid leukemia, suggesting potential for post-transplant therapy.

Key Points

  • Menin-inhibition significantly enhances T-cell activation and granzyme A expression in acute myeloid leukemia.
  • Analysis revealed increased levels of interferon-stimulated genes linked to the T-cell activation following menin-inhibition treatment.
  • Transcriptomic profiling demonstrated altered gene expression and chromatin interactions linked to menin and nucleophosmin mutations.
  • These findings suggest menin-inhibition may be beneficial as a post-allo-HCT therapeutic strategy against acute myeloid leukemia.

Cite This Study

Schwöbel et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6d2https://doi.org/10.1182/blood-2025-5862
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Menin-inhibition boosts CAR-T cell therapy against NPM1 mutated and KMT2A-rearranged acute myeloid leukemia2025 · 1 citations
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  3. 3Therapeutic Implications of Menin Inhibitors in the Treatment of Acute Leukemia: A Critical Review2025 · 7 citations
  4. 4HMGA1 chromatin regulators drive transcriptional networks governing cell cycle progression, immune escape, and menin-inhibitor resistance in KMT2A-r Acute Myeloid Leukemia2025
  5. 5Targeting menin in lysine methyltransferase 2A/nucleophosmin-mutated leukemia: A novel strategy from epigenetic dysregulation to clinical therapy (Review)2025