September 11, 2025Oncology LettersOpen Access

Targeting menin in lysine methyltransferase 2A/nucleophosmin-mutated leukemia: A novel strategy from epigenetic dysregulation to clinical therapy (Review)

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Discussion

Review highlights menin's dual role in gene expression and its potential for targeted therapy in AML, suggesting promising implications.

Menin inhibitors show promising efficacy in treating acute myeloid leukemia subtypes, especially KMT2A and NPM1 mutations.
Menin protein regulates gene expression through intricate interactions with various protein complexes and signaling pathways.
The review covers menin's biological roles and its challenges in drug development, especially regarding off-target effects.
Despite good progress in clinical development, issues such as resistance mechanisms and biomarker identification persist.

Bi et al. (2025) studied this question.

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