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December 8, 2025Blood

Significant improvement of bone marrow fibrosis in patients with chronic myeloproliferative neoplasms (CMPN) treated with ruxolitinib.

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Authors

PVPablo Vargas ViverosRMRafael Hurtado MonroyDEDiana Mendoza Elizarraraz

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Overview

Analysis demonstrates significant improvement in myelofibrosis grades in patients with CMPN, suggesting Ruxolitinib enhances survival rates.

Key Points

  • Improvement in myelofibrosis grades was observed, particularly in patients with thrombocythemia and polycythemia.
  • Six patients moved from fibrosis grade 3 to grade 1 after treatment with a median follow-up of 10 years.
  • The analysis was based on bone marrow biopsies from 16 patients, with equal gender representation and median age of 63.
  • These findings indicate the potential role of Ruxolitinib in treating myelofibrosis, warranting further studies.

Cite This Study

Viveros et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6bbhttps://doi.org/10.1182/blood-2025-7333
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A case report of ruxolitinib reversing myelofibrosis2025
  2. 2Long-term safety and effectiveness of ruxolitinib in patients with myelofibrosis in Japan: an observational study2025 · 4 citations
  3. 3Phase II Study of Peri- and Post-Transplant Ruxolitinib for Patients With Myelofibrosis Receiving Allogeneic Hematopoietic Cell Transplantation2025 · 6 citations
  4. 4Ruxolitinib versus allogeneic stem cell transplantation for patients with myelofibrosis according to donor availability: A prospective multicenter phase II trial2025
  5. 5Peri-transplant ruxolitinib therapy significantly improves GVHD-free, relapse-free survival rates in transplantation for myelofibrosis2025 · 1 citations