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December 8, 2025Blood

Prognostic impact of TP53 mutation status and variant allele frequency in myelodysplastic syndromes: A meta-analysis of prognosis and transplant outcomes

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Authors

DPDaniel Park

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Overview

Meta-analysis demonstrates that TP53 mutation status influences prognosis and transplant outcomes in myelodysplastic syndromes, suggesting improved risk stratification strategies.

Key Points

  • TP53 mutation status negatively impacts overall survival, with a pooled hazard ratio of 2.34 compared to wild-type patients.
  • Variant allele frequency of ≥30% correlates with poorer outcomes, exhibiting a hazard ratio of 2.16 against those with low VAF.
  • This meta-analysis evaluates 33 studies, encompassing 2,526 MDS patients where significant outcome differences were observed based on TP53 characteristics.
  • Findings highlight the necessity for integrating VAF into risk stratification for MDS patients, especially for those undergoing allogeneic stem cell transplant.

Cite This Study

Daniel Park (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a4https://doi.org/10.1182/blood-2025-7393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative outcome and prognostic factor analysis among MDS/AML patients with TP53 mutations, snps, and wild type2025 · 4 citations
  2. 2Clinical implications of TP53 mutations (TP53MT) in patients (pts) with higher risk Myelodysplastic Syndromes (HR-MDS) treated with hypomethylating agents (HMA) and allogeneic hematopoietic transplantation (allo-HCT): An analysis from the international consortium of MDS (icMDS) validate database2025
  3. 3Functional classification of monoallelic TP53 mutations refines prognostic stratification in myelodysplastic neoplasms2025
  4. 4Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes2025
  5. 5Acute Myeloid Leukemia (AML) with TP53 alteration and outcomes after allogeneic hematopoietic stem cell transplantation: A CIBMTR registry study2025 · 1 citations