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December 8, 2025BloodOpen Access

Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes

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Authors

LJLong JingPLPeihua Lu

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Overview

Retrospective analysis shows TP53 mutations influence relapse risk and survival in acute leukemia and MDS patients post-transplantation.

Key Points

  • Multi-hit TP53 mutations are linked to increased relapse risk and poorer overall survival in patients.
  • Survival rates differ significantly between single-TP53mut and multi-TP53mut groups, with lower 2-year overall survival.
  • Patients achieving remission before allogeneic transplantation had better outcomes and lower non-relapse mortality rates.
  • Analysis included 272 patients with TP53 mutations undergoing transplantation between 2019 and 2023.

Cite This Study

Jing et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e51ehttps://doi.org/10.1182/blood-2025-2493
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