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December 8, 2025BloodOpen Access

Older age and complex karyotype are the main predictors of mortality irrespective of allogeneic transplant in therapy-related myeloid neoplasms: A single‑center retrospective cohort

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JMJ Mantovani

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Overview

Retrospective cohort shows age and complex karyotype as key mortality predictors in therapy-related myeloid neoplasms, suggesting prioritizing prevention of these malignancies.

Key Points

  • Mortality in therapy-related myeloid leukemias is notably driven by age and complex karyotype, emphasizing the urgency for targeted preventive measures.
  • Cumulative incidence of therapy-related myeloid neoplasms-related mortality reaches 63% within two years, severely impacting patient prognosis.
  • Analysis leveraged Fine and Gray models to identify complex karyotype and older age as significant mortality risk factors among 86 patients.
  • Significant findings indicate that results advocate for strategies to mitigate therapy-related malignancy occurrences, addressing age-related risks.

Cite This Study

J Mantovani (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d672https://doi.org/10.1182/blood-2025-5161
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  3. 3Outcomes of allogeneic hematopoietic cell transplant (HCT) in patients with TP53-altered acute leukemia or myelodysplastic syndrome: A retrospective single center analysis2025
  4. 4Patients with TP53-mutated AML/MDS without complex or monosomal karyotype can achieve durable survival benefits with allogeneic HCT2025 · 1 citations
  5. 5Impact of pre-allogeneic stem cell transplantation (SCT) disease characteristics, therapy, and response on post-SCT outcomes in higher risk myelodysplastic syndromes2025 · 1 citations