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December 8, 2025Blood

Impact of pre-allogeneic stem cell transplantation (SCT) disease characteristics, therapy, and response on post-SCT outcomes in higher risk myelodysplastic syndromes

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Authors

GGGuillermo Garcia‐ManeroÁBÁlex BatallerGMGuillermo Montalban‐Bravo

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Overview

Observational analysis shows TP53 mutations correlate with poor outcomes in higher-risk MDS, indicating need for alternative strategies.

Key Points

  • Overall survival was significantly worse in patients with TP53 biallelic mutations compared to wild type.
  • Multivariate analysis identified factors such as IPSS-R very high risk and TP53 status as impacting overall survival.
  • Cumulative incidence rates revealed a 5-year relapse rate of 37% in patients after allogeneic SCT.
  • Patients treated with venetoclax as a pre-SCT regimen showed trends towards improved survival outcomes.

Cite This Study

Garcia‐Manero et al. (2025) studied this question.

synapsesocial.com/papers/69362f764fa91c937236e42ahttps://doi.org/10.1182/blood-2025-6075
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