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December 8, 2025BloodOpen Access

Thrombotic thrombocytopenic purpura-related mortality trends among the United States population: A retrospective study using the CDC wonder database

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Authors

MKMehandar Kumar

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Overview

Retrospective analysis identifies declining mortality trends in TTP, revealing significant racial disparities and healthcare access challenges.

Key Points

  • Mortality trends for thrombotic thrombocytopenic purpura show a significant decline since 1999, indicating improved health outcomes.
  • Between 1999 and 2020, the age-adjusted mortality rate fell from 0.20 to 0.07 per 100,000 population, reflecting about a 65% reduction.
  • Analysis using ICD-10 coding and Joinpoint regression revealed notable disparities in mortality rates among different demographics.
  • Ongoing disparities in healthcare access highlight the need for targeted public health interventions to reduce preventable TTP-related deaths.

Cite This Study

Mehandar Kumar (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d62bhttps://doi.org/10.1182/blood-2025-1332
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  1. 1Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years2025
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  3. 3Ethnic, racial, and geographic disparities in idiopathic thrombocytopenic purpura related mortality along the US-Mexico border from 1999 to 20202025
  4. 4Rapid decrease in age-adjusted mortality rates associated with ITP following eltrombopag aand romiplostin approvals, but not in TMA following eculizumab approval, 1999-20232025
  5. 5Prognostic Relevance of Early Clinical and Laboratory Findings in Immune-Mediated Thrombotic Thrombocytopenic purpura2025