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September 10, 2025Research and Practice in Thrombosis and HaemostasisOpen Access

Prognostic Relevance of Early Clinical and Laboratory Findings in Immune-Mediated Thrombotic Thrombocytopenic purpura

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Authors

AHAtsushi HamamuraKSKazuya SakaiTMToshiki Mushino

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Overview

Analysis reveals lactate dehydrogenase levels predict worse outcomes in patients with iTTP, highlighting the need for targeted monitoring.

Key Points

  • Elevated lactate dehydrogenase levels correlated with poorer prognosis in iTTP patients, emphasizing its prognostic value.
  • Among 125 patients, 15 died, with 5 deaths directly related to immune-mediated thrombotic thrombocytopenic purpura.
  • Analysis of registries included cardiac findings, neurologic symptoms, and troponin I levels, revealing limited predictive value.
  • Findings indicate that early cardiac and neurologic symptoms may not reliably predict iTTP-related death, thus redefining monitoring efforts.

Cite This Study

Hamamura et al. (2025) studied this question.

synapsesocial.com/papers/68c23f1fb210217d647957ddhttps://doi.org/10.1016/j.rpth.2025.102974
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Progression From Early Multiterritorial Punctate Infarcts to Massive Stroke in Fulminant Thrombotic Thrombocytopenic Purpura Despite Aggressive Therapy: A Therapeutic Dilemma in Initiating Antithrombotic Therapy2025
  2. 2Prognostic value of laboratory biomarkers for mortality risk stratification in thrombotic thrombocytopenic purpura2025
  3. 3Thrombotic thrombocytopenic purpura-related mortality trends among the United States population: A retrospective study using the CDC wonder database2025
  4. 4Association of Therapeutic Plasma Exchange-Treated Thrombotic Thrombocytopenic Purpura with Improved Mortality Outcome in End-Stage Renal Disease2025
  5. 5A peculiar case report of primary iTTP in a previously healthy Saudi man.2025