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December 8, 2025BloodOpen Access

Single-cell immune landscape associated with isatuximab, carfilzomib, lenalidomide, and dexamethasone induction efficacy in newly diagnosed myeloma

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Authors

HAHervé Avet‐LoiseauJCJill CorreLMLudovic Martinet

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Overview

Single-cell analysis reveals immune dynamics and minimal residual disease correlation in multiple myeloma, suggesting insights for therapy optimization.

Key Points

  • MRD-positive patients showed distinct immune signatures, highlighting treatment resistance patterns.
  • Analysis of single-cell RNA sequencing on immune cells across 85 NDMM patients provides insights into immune response.
  • Dexamethasone and proteasome inhibitors significantly altered immune cell populations and functions post-induction.
  • Understanding these immune dynamics may lead to improved immune-based interventions in multiple myeloma.

Cite This Study

Avet‐Loiseau et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d603https://doi.org/10.1182/blood-2025-3932
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  1. 1Daratumumab-based quadruplet therapy in functional high-risk relapse/refractory multiple myeloma patients induces changes associated with CD8 T cell signaling, activation and expansion2025
  2. 2Low conversion rates to minimal residual disease (MRD) negativity despite improved IMWG responses with lenalidomide-isatuximab maintenance after autologous stem cell transplant (ASCT) in multiple myeloma.2025
  3. 3The resistec study: Dissecting immune correlates of resistance and response to teclistamab in real-world multiple myeloma2025
  4. 4MRD dynamics predicts progression and reveals a vulnerable state for immunotherapy interception in multiple myeloma2026
  5. 5Single-cell multiomics reveals molecular identities and clonal dynamics of MRD progression in Myelodysplastic Syndromes after stem cell transplant2025