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December 8, 2025Blood

Biology of circulating tumor cells (CTCs) in multiple myeloma (MM): Comparative transcriptomic profiling reveals egression-associated changes related to CTC burden

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Authors

EREva RadovaOVOndrej VenglárLBLucie Broskevičová

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Overview

Comparative transcriptomic profiling reveals CTC gene expression differences in multiple myeloma, indicating potential mechanisms of plasma cell egression.

Key Points

  • CTC gene expression was notably different from paired BM plasma cells, with implications for prognostic outcomes.
  • We identified the gene CD44 as significantly altered in circulating tumor cells, suggesting its relevance in egression mechanisms.
  • Analysis employed next-generation flow cytometry and differential gene expression methods to derive insights in multiple myeloma cases.
  • Findings highlight the association of cytogenetic features with CTC scores, suggesting relevance for treatment resistance and disease progression.

Cite This Study

Radova et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5fdhttps://doi.org/10.1182/blood-2025-3927
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotypic evolution of circulating tumor plasma cells across MGUS, SMM and multiple myeloma2025
  2. 2Circulating tumor plasma cells as an independent prognostic marker in newly diagnosed multiple myeloma: Clinical correlation and immunophenotypic insights2025
  3. 3Surface protein-focused gene expression analysis identifies prognostic immunophenotypes in newly diagnosed multiple myeloma2025
  4. 4Circulating tumor cells (CTCs) improve risk stratification according to the second revision of the international staging system (R2-ISS) and the ims-IMWG consensus genomic staging (CGS) in newly diagnosed multiple myeloma (NDMM): An analysis from the european CTC consortium.2025
  5. 5Monoclonal and polyclonal circulating plasma cells (CPCs) are linked to disease spread in multiple myeloma2025