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December 8, 2025Blood

Circulating tumor plasma cells as an independent prognostic marker in newly diagnosed multiple myeloma: Clinical correlation and immunophenotypic insights

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Authors

JZJieqiong ZhouWYWenqiang YanJXJingyu Xu

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Overview

Observational analysis showed circulating tumor plasma cells correlate with adverse features and reduced progression-free survival in multiple myeloma, suggesting their role as prognostic biomarkers.

Key Points

  • Patients with higher circulating tumor plasma cells face reduced progression-free survival compared to those with lower levels.
  • CTPC levels are significantly associated with high-risk disease features including advanced disease stages and cytogenetic abnormalities.
  • Assessment using multiparametric flow cytometry revealed immunophenotypic insights into circulating tumor plasma cells versus bone marrow plasma cells.
  • Results highlight the potential of baseline circulating tumor plasma cells for therapeutic guidance in newly diagnosed multiple myeloma.

Cite This Study

Zhou et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236e012https://doi.org/10.1182/blood-2025-5761
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