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September 11, 2025Open Access

Single-cell RNA sequencing identifies subtypes of cancer-associated fibroblasts in early and late stages of mycosis fungoides.

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Authors

CJC. JohnsonWLWeishan LiSSSoroosh Solhjoo

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Overview

Single-cell RNA sequencing uncovers cancer-associated fibroblast subtypes in mycosis fungoides, highlighting implications for tumor interactions and disease progression.

Key Points

  • Nine distinct fibroblast subclusters identified in mycosis fungoides, impacting understanding of tumor interactions.
  • Vascular/metabolic fibroblasts predominated in early-stage mycosis fungoides, correlating with disease characteristics.
  • An antigen-presenting fibroblast subtype linked to chronic T-cell exhaustion reveals new potential therapeutic targets.
  • Single-cell RNA sequencing provides advanced insight into the tumor microenvironment's role in cancer progression.

Cite This Study

Johnson et al. (2025) studied this question.

synapsesocial.com/papers/68d418cd713b0b5dfea641e2https://doi.org/10.1101/2025.09.07.25335167
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