December 8, 2025Blood

The feasibility of collecting social determinants of health in the national multi-center GRASP sickle cell gene therapy trial

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Discussion

Observational analysis revealed 100% survey completion about poverty in sickle cell patients, suggesting significant data collection feasibility.

Poverty exposure was reported by 38% of participants, indicating a substantial need for targeted support.
Surveys assessed household material hardship, including food and housing insecurities, demonstrating importance of socioeconomic factors.
A total of 24 out of 24 participants completed the survey, highlighting the feasibility of such data collection in clinical trials.
Integration of social determinants of health data is critical for improving access to essential treatments in this patient population.

London et al. (2025) studied this question.

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Observational analysis revealed 100% survey completion about poverty in sickle cell patients, suggesting significant data collection feasibility.