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December 8, 2025BloodOpen Access

Tumor-specific risk of acute kidney injury: A multi-cancer comparison across matched real-world cohorts

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Authors

PKPierre Khoury

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Overview

Retrospective analysis demonstrated higher acute kidney injury risk in acute myeloid leukemia and multiple myeloma with alcohol compared to other malignancies, highlighting the need for targeted fluid

Key Points

  • AML patients had the highest acute kidney injury rates at 29.5%, significantly exceeding those of MM patients at 20.3%.
  • Multiple myeloma with alcohol disorders exhibited a 35.7% acute kidney injury risk, compared to 22.7% without, indicating a substantial elevation.
  • This analysis utilized matched cohort studies and propensity score methods to ensure comparability across malignancy populations.
  • The findings emphasize the importance of tailored supportive care strategies and early nephrology referrals to mitigate renal complications.

Cite This Study

Pierre Khoury (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4c6https://doi.org/10.1182/blood-2025-3672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of acute kidney injury on mortality and resource utilization in hospitalized patients with multiple myeloma2025
  2. 2Evolving burden of acute kidney injury in non-Hodgkin's lymphoma hospitalizations: A seven-year nationwide study2025
  3. 3Association of acute kidney injury with in-hospital mortality and resource utilization among U.S. solid tumor hospitalizations: A National Inpatient Sample analysis, 2018–2022.2026
  4. 4Acute kidney injury associated with cancer therapies: A focus on conventional chemotherapies and targeted treatments2026
  5. 5Nephrotoxicity and kidney outcomes in pediatric oncology patients2025 · 3 citations