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August 22, 2025Nephrology Dialysis TransplantationOpen Access

Nephrotoxicity and kidney outcomes in pediatric oncology patients

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Authors

PRPaulien A. M. A. Raymakers-JanssenUniversity Medical Center UtrechtNLNils LeitzingerUniversity of OsloGBGerrit van den BergPrincess Máxima Center

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Implication

Retrospective cohort study shows a 37% AKI rate in pediatric cancer patients, indicating nephrotoxic medications intensify CKD risk.

Key Points

  • Acute kidney injury is common in pediatric oncology, with 37% of patients affected during treatment.
  • Increased risk factors include nephrotoxic medications like ifosfamide and amphotericin B, alongside older age.
  • High incidence of chronic kidney disease was noted, with 13.6% of patients showing eGFR < 90 mL/min/1.73 m² one year post-treatment.
  • Monitoring strategies are crucial for early detection of AKI and timely intervention to prevent CKD.

Cite This Study

Raymakers-Janssen et al. (2025) studied this question.

synapsesocial.com/papers/68af707c7567bf4f94fec6a6https://doi.org/10.1093/ndt/gfaf169
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