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December 8, 2025Blood

Impact of high-dose methotrexate in both central nervous system relapse and systemic progression in high-risk DLBCL: A retrospective analysis of a brazilian cohort

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Authors

FHFrederico HonoratoHospital Israelita Albert Einstein TOThaís de OliveiraHospital Municipal São José LTLarissa TeixeiraHospital Israelita Albert Einstein

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Implication

Retrospective analysis shows high-dose methotrexate reduces disease progression in high-risk DLBCL patients, indicating potential for improved outcomes.

Key Points

CNS relapse occurred in 10.2% of patients with high-risk DLBCL, often associated with a poor prognosis, showing the urgency of effective interventions.
Progression-free survival was significantly improved in patients receiving high-dose methotrexate, with an odds ratio of 0.26 suggesting a notable benefit.
Retrospective analysis utilized logistic regression to assess associations between CNS prophylaxis and outcomes in patients with aggressive B-cell lymphomas.
Findings suggest potential benefits of high-dose methotrexate in reducing systemic disease progression despite risks of toxicity observed in treatment.

Cite This Study

Honorato et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4c3 https://doi.org/10.1182/blood-2025-3673

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Implication

Retrospective analysis shows high-dose methotrexate reduces disease progression in high-risk DLBCL patients, indicating potential for improved outcomes.

Impact of high-dose methotrexate in both central nervous system relapse and systemic progression in high-risk DLBCL: A retrospective analysis of a brazilian cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Impact of high-dose methotrexate in both central nervous system relapse and systemic progression in high-risk DLBCL: A retrospective analysis of a brazilian cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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