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This is a Validation Study study.

December 8, 2025Blood

Prognostic and therapeutic implications of the immune landscape in Mantle Cell Lymphoma

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Analysis reveals immune subtypes predict prognosis and treatment response in mantle cell lymphoma, highlighting unique gene expression profiles.

Immune subtypes stratify mantle cell lymphoma with distinct prognostic profiles and clinical outcomes.
IM1 shows a favorable prognosis with high immune scores and checkpoint expression, while IM3 exhibits genomic instability and ibrutinib resistance.
Research utilized gene expression profiles from 403 mantle cell lymphoma samples across 8 GEO datasets for immune characterization.
Findings support the development of a prognostic model for patient risk assessment in mantle cell lymphoma.

Zhu et al. (2025) studied this question.

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Analysis reveals immune subtypes predict prognosis and treatment response in mantle cell lymphoma, highlighting unique gene expression profiles.