What type of study is this?

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial).

What question did this study set out to answer?

This research aims to investigate the tumor microenvironment and its heterogeneity in mantle-cell lymphoma.

December 8, 2025BloodOpen Access

Single-cell transcriptomic profiling reveals tumor-intrinsic heterogeneity and immune-microenvironment dynamics in the order trial for mantle-cell lymphoma

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Authors

XSXiaozhong ShenNantong University WZWeili ZhaoShanghai Jiao Tong University LWLi WangShanghai Jiao Tong University

Discussion

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Implication

Single-cell RNA sequencing unveils immune microenvironment dynamics and tumor heterogeneity in mantle-cell lymphoma, suggesting biomarkers for treatment response.

Key Points

This research aims to investigate the tumor microenvironment and its heterogeneity in mantle-cell lymphoma.
Conducted a multicenter trial with untreated mantle-cell lymphoma patients
Performed single-cell RNA sequencing on samples from 33 patients
Analyzed cell populations and immune microenvironment characteristics
Identified distinct B cell and T cell subclusters within the tumor microenvironment
Observed differences in immune cell populations between classical and blastoid mantle-cell lymphoma
Linked tumor heterogeneity to treatment response and potential biomarkers

Cite This Study

Shen et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d276 https://doi.org/10.1182/blood-2025-1792

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Implication

Single-cell RNA sequencing unveils immune microenvironment dynamics and tumor heterogeneity in mantle-cell lymphoma, suggesting biomarkers for treatment response.