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December 8, 2025BloodOpen Access

Impact of graft versus host disease prophylaxis with post transplant cyclophosphamide on the prognostic value of HCT-CI

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Authors

AMAnsh MehtaHKHaesook KimVHVincent T. Ho

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Overview

Observational analysis shows that HCT-CI maintains prognostic significance in acute myeloid leukemia patients, suggesting improved risk assessment could enhance post transplant outcomes.

Key Points

  • Graft versus host disease prophylaxis using post transplant cyclophosphamide retains prognostic significance based on HCT-CI.
  • Patients with acute myeloid leukemia showed a 22% higher cumulative incidence of non-relapse mortality with increased HCT-CI scores.
  • Analysis employed multivariable Fine and Gray regression with a detailed evaluation of comorbidities affecting outcomes.
  • Results underscore the need for closer scrutiny of cardiac toxicity and comorbidities to mitigate non-relapse mortality risks.

Cite This Study

Mehta et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236defahttps://doi.org/10.1182/blood-2025-4227
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Post-transplant cyclophosphamide based GVHD prophylaxis in HLA-matched related and unrelated donor hematopoietic cell transplantation in adults with hematologic malignancies undergoing myeloablative conditioning: A CIBMTR analysis of 8,272 participants2025
  2. 2Comorbid but transplantable: Favorable outcomes with RIC and ptcy in patients with an HCT-CI score of 3 or higher in the modern era2025
  3. 3Post-transplant cyclophosphamide-based graft-verses-host disease (GVHD) prophylaxis is associated with a low incidence of fibrotic chronic GVHD after allogeneic hematopoietic cell transplantation across diverse donor types2025
  4. 4Post-transplant cyclophosphamide in haploidentical stem cell transplantation: evaluating the impact of transplant conditioning intensity2025
  5. 5Safety and efficacy of post transplant cyclophosphamide vs tacrolimus plus methotrexate for gvhd prophylaxis in myelofibrosis2025