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December 8, 2025BloodOpen Access

Impact of cohesin complex gene mutations on clinical outcomes in Acute Myeloid Leukemia

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Authors

MAMoath AlbliwiJHJohn HannaDNDaniel Paul Nurse

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Overview

Retrospective analysis reveals gene mutations impact survival and response rates in acute myeloid leukemia, suggesting implications for targeted therapies.

Key Points

  • Cohesin complex gene mutations significantly affected clinical outcomes in acute myeloid leukemia.
  • In a cohort of 971 patients, overall survival rates varied by specific gene mutations and treatment responses.
  • Next-Generation Sequencing was utilized to determine gene mutation status among patients newly diagnosed with AML.
  • Understanding these mutations' prognostic significance may enable improved targeted therapy approaches for myeloid malignancies.

Cite This Study

Albliwi et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3cbhttps://doi.org/10.1182/blood-2025-4626
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Increased prevalence of alternative splicing in core-cohesin subunit mutated AML as compared to STAG2 mutated AML2025
  2. 2Additional myelodysplasia-related genes mutations affected the clinical presentations and prognosis of patients with SRSF2/TET2 co-mutations2025
  3. 3Epigenetic dysregulation of the polycomb axis in Acute Myeloid Leukemia: Clinical and prognostic correlates2025
  4. 4Investigating suspected germline STAG2 variants in myeloid neoplasms2025
  5. 5Prognostic impact of co-occurring mutations in NPM1-mutated Acute Myeloid Leukemia2025