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December 8, 2025BloodOpen Access

A human IL-6–Expressing PDX model of multiple myeloma recapitulates clinical features and supports patient-derived tumor engraftment

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Authors

YZYan ZengVSVeronica SteriESElliot Stieglitz

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Overview

This human PDX model demonstrates stable IL-6 expression and anemia in multiple myeloma, highlighting its utility for therapies targeting disease biology.

Key Points

  • Bone disease and anemia were notable outcomes in the IL-6 PDX model of multiple myeloma, as measured by complete blood counts.
  • Mean hemoglobin in engrafted mice was 10.7 g/dL, indicating anemia compared to controls with 14.3 g/dL.
  • Engraftment stability and immunophenotype were monitored through flow cytometry and serum protein electrophoresis.
  • This model serves as a valuable resource for investigating therapeutic targets like exome sequencing and CAR-T cell therapies.

Cite This Study

Zeng et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3a8https://doi.org/10.1182/blood-2025-3943
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In Vivo postnatal loss of mature osteoblasts creates an immunosuppressive bone marrow microenvironment to permit the engraftment and proliferation of myeloma cells2025
  2. 2Development of NOG-W41-based humanized mouse model for studying In Vivo human hematopoiesis2025
  3. 3Optimizing establishment of high need pediatric Acute Myeloid Leukemia (AML) patient derived xenograft (PDX) models2025
  4. 4Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immunotherapies2025 · 1 citations
  5. 5A novel spontaneous HLH mouse model by engrafting human HSCs into b-ndg MGMT3 mice2025