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September 18, 2025Frontiers in ImmunologyOpen Access

Tumor-dependent myeloid and lymphoid cell recruitment in genO-BRGSF-HIS mice: a novel tool for evaluating immunotherapies

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Authors

GMGaëlle MartinGenoway (France)SHSiham HedirGenoway (France)FCFlorent CreusatGenoway (France)

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Implication

Preclinical model reveals functional lymphoid and myeloid cell recruitment in tumor microenvironment, suggesting new immunotherapy applications.

Key Points

  • Myeloid and lymphoid cells are functional and recruited to the tumor microenvironment in genO-BRGSF-HIS mice, enhancing tumor immunity.
  • The study shows that tumor type and burden influence immune cell composition in the tumor microenvironment, indicating adaptability.
  • This model employs human CD34 + cord blood cells, allowing an accurate representation of human immune response in cancer research.
  • Extended lifespan of genO-BRGSF-HIS mice supports prolonged experimental timelines for testing novel immunotherapies.

Cite This Study

Martin et al. (2025) studied this question.

synapsesocial.com/papers/68d434ea713b0b5dfea745fbhttps://doi.org/10.3389/fimmu.2025.1624724
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