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December 8, 2025BloodOpen Access

Monoclonal antibodies against pathogenic S100A8/9 alarmins can restore hematopoiesis and result in immunomodulation in myelodysplasia and leukemia models

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Authors

SASrinivas AluriSASarah AminovLKLeah Kravets

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Overview

Analysis finds S100A8/9 antibodies improve hematopoiesis in leukemia, suggesting they may help reverse cytopenias.

Key Points

  • Monoclonal antibodies improved hematopoiesis by increasing erythroid colony formation and differentiation in leukemia models.
  • Study revealed increased S100A8/9 expression linked to greater RBC transfusion dependency and lower hemoglobin levels.
  • Analysis of leukemia patient-derived cells confirmed S100A8/9 as targets for immunomodulation and hematopoiesis restoration.
  • Findings support the clinical development of S100A8/9 antibodies to address the immunosuppressive microenvironment in myeloid malignancies.

Cite This Study

Aluri et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d377https://doi.org/10.1182/blood-2025-4959
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.2025
  2. 2Pediatric Acute Myeloid Leukemia associated S100A9 promotes T cell dysfunction2025
  3. 3Critical role of niche S100A8 for acute myeloid leukemia progression and hematopoiesis regeneration2025 · 4 citations
  4. 4Myeloid-specific S100A8/A9 deficiency attenuates atrial fibrillation through prevention of TLR4/NF-kB-mediated immune cell recruitment and inflammation2025 · 3 citations
  5. 5Paquinimod regulate megakaryocyte function by restoring mitochondrial oxidative phosphorylation in acute myeloid leukemia2025