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September 10, 2025Blood AdvancesOpen Access

Critical role of niche S100A8 for acute myeloid leukemia progression and hematopoiesis regeneration

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Authors

XLXiaoyan LiuJWJinxian WuXLXinqi Li

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Overview

Research shows S100A8 drives acute myeloid leukemia growth in mice, suggesting inflammation impacts hematopoiesis.

Key Points

  • Inhibition of S100A8 led to prolonged survival and reduced AML cell infiltration in murine models.
  • Elevated S100A8 levels in mesenchymal stromal cells increased AML cell proliferation significantly.
  • S100A8 activates the PI3K/Akt pathway in leukemia cells, influencing their growth and survival.
  • Removal of S100A8 temporarily decreased hematopoietic stem cells, but improved long-term regeneration.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68c23cf6b210217d6478baadhttps://doi.org/10.1182/bloodadvances.2024015762
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