Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Characterization of bone marrow B-cells in patients with warm autoimmune hemolytic anemia by single-cell analysis

View Full Paper
Ask AI
Bookmark
Share

Authors

FLFrancesca LazzaroniNBNiccolò BolliWBWilma Barcellini

Discussion

Loading...

Member takes

Overview

Single-cell RNA sequencing reveals B-cell gene expression patterns in warm autoimmune hemolytic anemia, highlighting relapse-related hypoxia and corticosteroids responses.

Key Points

  • Increased immature B-cells are observed at relapse in patients with warm autoimmune hemolytic anemia, indicating a shift in B-cell profiles.
  • Specific gene expression changes, especially in hypoxia pathways and TNF-alpha signaling, are notable at relapse compared to remission.
  • Single-cell RNA sequencing allowed detailed analysis of bone marrow B-cells in patients compared to healthy donors.
  • These findings suggest potential new targets for therapy in the management of warm autoimmune hemolytic anemia.

Cite This Study

Lazzaroni et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d327https://doi.org/10.1182/blood-2025-1122
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bone marrow microenvironment in autoimmune hemolytic anemia: from trephine biopsy to single cell RNA sequencing2025 · 4 citations
  2. 2[Future directions in the management of warm autoimmune hemolytic anemia].2025
  3. 3Real-world evidence from China: Clinical characteristics, treatment landscape and long-term outcomes in 566 autoimmune hemolytic anemia patients2025
  4. 4Heterogeneity of treatment regimens and related health resource use in managing patients with waiha: A US multi-database retrospective observational Study2025
  5. 5Severe Warm Autoimmune Hemolytic Anemia With Profound Anemia Requiring Multimodal Immunosuppressive Therapy2026