Analysis of bone marrow features reveals T-cell infiltration and cytokine variations in 97 patients with autoimmune hemolytic anemia, indicating disease severity.
Key Points
Patients with autoimmune hemolytic anemia exhibited high rates of hypercellularity and dyserythropoiesis, indicating severe disease and adverse outcomes.
Inadequate reticulocytosis was associated with more severe anemia and the need for multiple treatments in autoimmune hemolytic anemia patients.
Single-cell RNA sequencing revealed distinct immune cell profiles, with inflammatory pathways upregulated in CD8 + and CD4 + T cells during relapse.
The study provides new insights into the bone marrow microenvironment in autoimmune hemolytic anemia, highlighting T-cell dynamics and cytokine regulation.